If Valtrex (valacyclovir) isn’t right for you—because of cost, side effects, or resistance—you still have good options. Some work the same way but cost less; others are better for cold sores or for people with resistant infections. Below I list the practical choices you can discuss with your doctor and what to expect from each.
Acyclovir (Zovirax). This is the original antiviral that valacyclovir turns into in the body. For shingles, a typical adult dose is 800 mg five times a day for 7–10 days; for genital herpes there are shorter-course options. Acyclovir is widely available as a generic and is usually cheaper than valacyclovir. It needs more frequent dosing, though, which can be inconvenient.
Famciclovir (Famvir). Famciclovir is another oral antiviral used for shingles and recurrent herpes. A common regimen for shingles is 500 mg three times a day for 7 days. Some people tolerate it better than acyclovir and valacyclovir. Like the others, you’ll need a prescription and your doctor will adjust dosing for kidney problems.
IV options for severe or resistant infections. If oral drugs fail—often in immunocompromised patients—doctors may use IV acyclovir. For cases with proven resistance to acyclovir/valacyclovir, drugs like foscarnet (IV) are options, but they come with more risks and require hospital care.
Penciclovir cream and acyclovir cream are used for cold sores. They must be applied early to help speed healing. If you want OTC help, docosanol (Abreva) 10% cream can shorten a cold sore if started at the first tingle.
Supplements and prevention. People ask about lysine, zinc, and topical remedies. Evidence is mixed; these may help a bit for some people but are not replacements for prescription antivirals. For shingles prevention, the Shingrix vaccine is the proven option—talk to your clinician about it if you’re eligible.
Practical tips: start antiviral treatment as soon as symptoms begin for the best effect, finish the full course your provider prescribes, and avoid sexual contact during active genital outbreaks. Mention kidney disease or pregnancy to your prescriber—dosing and choices change. If cost is the issue, generic acyclovir or pharmacy discount programs may lower your bill.
Want to switch from Valtrex? Bring this list to your next appointment and ask about pros, cons, and dosing for your situation. Your doctor can pick the safest, most effective option based on your health and the type of infection.
This article explores seven effective alternatives to the medication Valtrex, which is used for treating herpes-related infections. Each alternative is explained in detail, highlighting their specific uses, advantages, and potential drawbacks. From traditional antivirals like Acyclovir and Famciclovir to topical treatments such as Penciclovir and Docosanol, the article covers various options based on their effectiveness and application. Ibuprofen and Lidocaine are discussed for their role in symptomatic relief, while Sitavig offers a unique approach to treating cold sores.